› › Function and Biology

STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.

Source organism: Homo sapiens
Biochemical function: Rho GDP-dissociation inhibitor binding
Biological process: actin cytoskeleton organization
Cellular component: ficolin-1-rich granule membrane

Quick links

EC 3.6.5.2: Small monomeric GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00071
Domain description: Ras family
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
The deposited structure of PDB entry 2yin contains 2 copies of Pfam domain PF00071 (Ras family) in Ras-related C3 botulinum toxin substrate 1. Showing 1 copy in chain D.

PF20421
Domain description: DHR-2, Lobe C
Occurring in:
  1. Dedicator of cytokinesis protein 2
The deposited structure of PDB entry 2yin contains 2 copies of Pfam domain PF20421 (DHR-2, Lobe C) in Dedicator of cytokinesis protein 2. Showing 1 copy in chain A.

PF20422
Domain description: DHR-2, Lobe B
Occurring in:
  1. Dedicator of cytokinesis protein 2
The deposited structure of PDB entry 2yin contains 2 copies of Pfam domain PF20422 (DHR-2, Lobe B) in Dedicator of cytokinesis protein 2. Showing 1 copy in chain A.

PF06920
Domain description: DHR-2, Lobe A
Occurring in:
  1. Dedicator of cytokinesis protein 2
The deposited structure of PDB entry 2yin contains 2 copies of Pfam domain PF06920 (DHR-2, Lobe A) in Dedicator of cytokinesis protein 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001806
Domain description: Small GTPase
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
IPR003578
Domain description: Small GTPase Rho
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
IPR046773
Domain description: DOCKER, Lobe C
Occurring in:
  1. Dedicator of cytokinesis protein 2
IPR043162
Domain description: Dedicator of cytokinesis, C-terminal, lobe C
Occurring in:
  1. Dedicator of cytokinesis protein 2
IPR046770
Domain description: DOCKER, Lobe B
Occurring in:
  1. Dedicator of cytokinesis protein 2
IPR027357
Domain description: DOCKER domain
Occurring in:
  1. Dedicator of cytokinesis protein 2
IPR046769
Domain description: DOCKER, Lobe A
Occurring in:
  1. Dedicator of cytokinesis protein 2
IPR026799
Domain description: Dedicator of cytokinesis protein 2, DHR2 domain
Occurring in:
  1. Dedicator of cytokinesis protein 2
IPR026791
Domain description: Dedicator of cytokinesis
Occurring in:
  1. Dedicator of cytokinesis protein 2
IPR043161
Domain description: Dedicator of cytokinesis, C-terminal, lobe A
Occurring in:
  1. Dedicator of cytokinesis protein 2

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
The deposited structure of PDB entry 2yin contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Ras-related C3 botulinum toxin substrate 1. Showing 1 copy in chain D.
1.20.58.740
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Occurring in:
  1. Dedicator of cytokinesis protein 2
The deposited structure of PDB entry 2yin contains 2 copies of CATH domain 1.20.58.740 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in Dedicator of cytokinesis protein 2. Showing 1 copy in chain A.
1.25.40.410
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Occurring in:
  1. Dedicator of cytokinesis protein 2
The deposited structure of PDB entry 2yin contains 2 copies of CATH domain 1.25.40.410 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Dedicator of cytokinesis protein 2. Showing 1 copy in chain A.

Quick links