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STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.

X-ray diffraction
2.7Å resolution
PDB entry 2yin coloured by chain, front view.
PDB entry 2yin coloured by chain, side view.
PDB entry 2yin coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dedicator of cytokinesis protein 2 and Ras-related C3 botulinum toxin substrate 1
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Multimeric state: hetero dimer
Accessible surface area: 28697.52 Å2
Buried surface area: 3722.82 Å2
Dissociation area: 1,861.41 Å2
Dissociation energy (ΔGdiss): 21.88 kcal/mol
Dissociation entropy (TΔSdiss): 13.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158908
Assembly 2
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Assembly Name: Dedicator of cytokinesis protein 2 and Ras-related C3 botulinum toxin substrate 1
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Multimeric state: hetero dimer
Accessible surface area: 28655.21 Å2
Buried surface area: 3709.21 Å2
Dissociation area: 1,854.6 Å2
Dissociation energy (ΔGdiss): 20.43 kcal/mol
Dissociation entropy (TΔSdiss): 13.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158908

Macromolecules

Dedicator of cytokinesis protein 2
Chains: A, B
Length: 436 amino acids
Theoretical weight: 51.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92608 (Residues: 1192-1622; Coverage: 24%)
Gene names: DOCK2, KIAA0209
Pfam:
InterPro:
CATH:
Dedicator of cytokinesis protein 2 in PDB entry 2yin, assembly 1, front view.
Dedicator of cytokinesis protein 2 in PDB entry 2yin, assembly 1, side view.
Dedicator of cytokinesis protein 2 in PDB entry 2yin, assembly 1, top view.
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Ras-related C3 botulinum toxin substrate 1
Chains: C, D
Length: 196 amino acids
Theoretical weight: 21.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63000 (Residues: 1-177; Coverage: 92%)
Gene names: MIG5, RAC1, TC25
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Ras-related C3 botulinum toxin substrate 1 in PDB entry 2yin, assembly 1, front view.
Ras-related C3 botulinum toxin substrate 1 in PDB entry 2yin, assembly 1, side view.
Ras-related C3 botulinum toxin substrate 1 in PDB entry 2yin, assembly 1, top view.
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