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Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase Sigma

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.1.3.48: Protein-tyrosine-phosphatase

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
  • (Phosphotyrosine)protein phosphatase
  • PPT-phosphatase
  • PTP-phosphatase
  • PTPase
  • Phosphoprotein phosphatase (phosphotyrosine)
  • Phosphotyrosine histone phosphatase
  • Phosphotyrosine phosphatase
  • Phosphotyrosine protein phosphatase
  • Phosphotyrosylprotein phosphatase
  • Protein phosphotyrosine phosphatase
  • Tyrosine O-phosphate phosphatase
  • Tyrosylprotein phosphatase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF13927
Domain description: Immunoglobulin domain
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase S
The deposited structure of PDB entry 2yd2 contains 1 copy of Pfam domain PF13927 (Immunoglobulin domain) in Receptor-type tyrosine-protein phosphatase S. Showing 1 copy in chain A.

PF07679
Domain description: Immunoglobulin I-set domain
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase S
The deposited structure of PDB entry 2yd2 contains 1 copy of Pfam domain PF07679 (Immunoglobulin I-set domain) in Receptor-type tyrosine-protein phosphatase S. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003598
Domain description: Immunoglobulin subtype 2
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase S
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase S
IPR013098
Domain description: Immunoglobulin I-set
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase S
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase S
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase S
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase S
IPR043204
Domain description: Basigin-like
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase S

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Receptor-type tyrosine-protein phosphatase S
The deposited structure of PDB entry 2yd2 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Receptor-type tyrosine-protein phosphatase S. Showing 2 copies in chain A.

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