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Structure of the regulatory fragment of mammalian aMPK in complex with two ADP

X-ray diffraction
2.5Å resolution
PDB entry 2y8l coloured by chain, front view.
PDB entry 2y8l coloured by chain, side view.
PDB entry 2y8l coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 5'-AMP-activated protein kinase
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Multimeric state: hetero trimer
Accessible surface area: 25077.52 Å2
Buried surface area: 8366.48 Å2
Dissociation area: 1,530.82 Å2
Dissociation energy (ΔGdiss): 9.93 kcal/mol
Dissociation entropy (TΔSdiss): 12.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129099

Macromolecules

5'-AMP-activated protein kinase catalytic subunit alpha-1
Chain: A
Length: 173 amino acids
Theoretical weight: 19.49 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P54645 (Residues: 407-555; Coverage: 27%)
Gene names: Ampk1, Prkaa1
Pfam: Adenylate sensor of SNF1-like protein kinase
InterPro:
CATH: Kinase associated domain 1, KA1
5'-AMP-activated protein kinase catalytic subunit alpha-1 in PDB entry 2y8l, assembly 1, front view.
5'-AMP-activated protein kinase catalytic subunit alpha-1 in PDB entry 2y8l, assembly 1, side view.
5'-AMP-activated protein kinase catalytic subunit alpha-1 in PDB entry 2y8l, assembly 1, top view.
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5'-AMP-activated protein kinase subunit beta-2
Chain: B
Length: 87 amino acids
Theoretical weight: 10.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43741 (Residues: 187-272; Coverage: 32%)
Gene name: PRKAB2
Pfam: 5'-AMP-activated protein kinase beta subunit, interaction domain
InterPro:
5'-AMP-activated protein kinase subunit beta-2 in PDB entry 2y8l, assembly 1, front view.
5'-AMP-activated protein kinase subunit beta-2 in PDB entry 2y8l, assembly 1, side view.
5'-AMP-activated protein kinase subunit beta-2 in PDB entry 2y8l, assembly 1, top view.
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5'-AMP-activated protein kinase subunit gamma-1
Chain: E
Length: 330 amino acids
Theoretical weight: 37.43 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P80385 (Residues: 1-330; Coverage: 100%)
Gene name: Prkag1
Pfam: CBS domain
InterPro:
5'-AMP-activated protein kinase subunit gamma-1 in PDB entry 2y8l, assembly 1, front view.
5'-AMP-activated protein kinase subunit gamma-1 in PDB entry 2y8l, assembly 1, side view.
5'-AMP-activated protein kinase subunit gamma-1 in PDB entry 2y8l, assembly 1, top view.
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