› 2y4q

Solution NMR

Solution structure of the EF-hand domain of Human Polycystin 2

Released:
DOI: 10.2210/pdb2y4q/pdb
PDB entry 2y4q coloured by chain, ensemble of 20 models, front view.
PDB entry 2y4q coloured by chain, ensemble of 20 models, side view.
PDB entry 2y4q coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
A high-resolution structure of the EF-hand domain of human polycystin-2.
Allen MD, Qamar S, Vadivelu MK, Sandford RN, Bycroft M
Protein Sci 23 1301-8 (2014)
PMID: 24990821

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycystin-2 Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 9.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13563 (Residues: 717-792; Coverage: 8%)
Gene names: PKD2, TRPP2
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 70%
Refinement method: ANNEAL.INP
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2.
Yang et al. (2016)
3 more

6 mentions without citation

Utility of Covalent Labeling Mass Spectrometry Data in Protein Structure Prediction with Rosetta.
Aprahamian et al. (2019)
5 more