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Crystal structure of LSD1-CoREST in complex with a N-terminal SNAIL peptide

X-ray diffraction
3Å resolution
PDB entry 2y48 coloured by chain, front view.
PDB entry 2y48 coloured by chain, side view.
PDB entry 2y48 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 38127.14 Å2
Buried surface area: 8594.91 Å2
Dissociation area: 2,682.62 Å2
Dissociation energy (ΔGdiss): 32.83 kcal/mol
Dissociation entropy (TΔSdiss): 13.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129947

Macromolecules

Lysine-specific histone demethylase 1A
Chain: A
Length: 730 amino acids
Theoretical weight: 81.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60341 (Residues: 123-852; Coverage: 86%)
Gene names: AOF2, KDM1, KDM1A, KIAA0601, LSD1
Pfam:
InterPro:
CATH:
Lysine-specific histone demethylase 1A in PDB entry 2y48, assembly 1, front view.
Lysine-specific histone demethylase 1A in PDB entry 2y48, assembly 1, side view.
Lysine-specific histone demethylase 1A in PDB entry 2y48, assembly 1, top view.
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REST corepressor 1
Chain: B
Length: 178 amino acids
Theoretical weight: 20.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKL0 (Residues: 308-485; Coverage: 37%)
Gene names: KIAA0071, RCOR, RCOR1
Pfam:
InterPro:
CATH: Methane Monooxygenase Hydroxylase; Chain G, domain 1
REST corepressor 1 in PDB entry 2y48, assembly 1, front view.
REST corepressor 1 in PDB entry 2y48, assembly 1, side view.
REST corepressor 1 in PDB entry 2y48, assembly 1, top view.
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Zinc finger protein SNAI1
Chain: C
Length: 20 amino acids
Theoretical weight: 2.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O95863 (Residues: 2-21; Coverage: 8%)
Gene names: SNAH, SNAI1
Zinc finger protein SNAI1 in PDB entry 2y48, assembly 1, front view.
Zinc finger protein SNAI1 in PDB entry 2y48, assembly 1, side view.
Zinc finger protein SNAI1 in PDB entry 2y48, assembly 1, top view.
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