Function and Biology Details
Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- SH2 domain
- Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- SH2 domain superfamily
- Phosphoinositide 3-kinase, accessory (PIK) domain
- Phosphatidylinositol 3-kinase, C2 domain
- Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
- Protein kinase-like domain superfamily
9 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Molecule details ›
Chain: A
Length: 1092 amino acids
Theoretical weight: 125.24 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 1092 amino acids
Theoretical weight: 125.24 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
Q8BTI9 (Residues: 1-1064; Coverage: 100%)
Sequence domains:
- Phosphoinositide 3-kinase family, accessory domain (PIK domain)
- Phosphatidylinositol 3- and 4-kinase
- PI3-kinase family, ras-binding domain
- Phosphoinositide 3-kinase C2
- PI3-kinase family, p85-binding domain
Phosphatidylinositol 3-kinase regulatory subunit beta
Molecule details ›
Chain: B
Length: 302 amino acids
Theoretical weight: 35.35 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: SH2 domain
Structure domains:
Length: 302 amino acids
Theoretical weight: 35.35 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: O08908 (Residues: 423-722; Coverage: 42%)
Sequence domains: SH2 domain
Structure domains:
