2y3a

X-ray diffraction
3.3Å resolution

Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Chain: A
Phosphatidylinositol 3-kinase regulatory subunit beta Chain: B
Molecule details ›
Chain: B
Length: 302 amino acids
Theoretical weight: 35.35 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O08908 (Residues: 423-722; Coverage: 42%)
Gene name: Pik3r2
Sequence domains: SH2 domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P6522
Unit cell:
a: 134.314Å b: 134.314Å c: 428.062Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.234 0.296
Expression system: Spodoptera frugiperda