› 2y01

X-ray diffraction
2.6Å resolution

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB102)

Released:
DOI: 10.2210/pdb2y01/pdb
PDB 2y01 coloured by chain and viewed from the front.
PDB 2y01 coloured by chain and viewed from the side.
PDB 2y01 coloured by chain and viewed from the top.
Source organism: Meleagris gallopavo
Primary publication:
The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor.
Warne T, Moukhametzianov R, Baker JG, Nehmé R, Edwards PC, Leslie AG, Schertler GF, Tate CG
OpenAccess logo Nature 469 241-4 (2011)
PMID: 21228877

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-1 adrenergic receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 35.94 KDa
Source organism: Meleagris gallopavo
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P07700 (Residues: 33-368; Coverage: 64%)
Gene name: ADRB1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins

Ligands and Environments

3 bound ligands:
Ligand Y01 4 x Y01
Ligand 2CV 10 x 2CV
Ligand Y00 2 x Y00
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 90.1Å b: 61.6Å c: 101.4Å
α: 90° β: 108.9° γ: 90°
R-values:
R R work R free
0.228 0.226 0.266
Expression system: Trichoplusia ni

Quick links

Citations

75 review citations

Cannabinoids and Cannabinoid Receptors: The Story so Far.
Shahbazi et al. (2020)
74 more

10 mentions without citation

Structural approaches to understanding retinal proteins needed for vision.
Orban et al. (2014)
9 more