2xrg

X-ray diffraction
3.2Å resolution

Crystal structure of Autotaxin (ENPP2) in complex with the HA155 boronic acid inhibitor

Released:
Source organism: Rattus norvegicus
Entry authors: Hausmann J, Albers HMHG, Perrakis A

Function and Biology Details

Reaction catalysed:
1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Chain: A
Molecule details ›
Chain: A
Length: 862 amino acids
Theoretical weight: 98.87 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q64610 (Residues: 1-887; Coverage: 97%)
  • Best match: Q64610-2 (Residues: 1-862)
Gene names: Atx, Enpp2, Npps2
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 63.995Å b: 90.204Å c: 152.672Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.255
Expression system: Homo sapiens