› 2xqy

X-ray diffraction
2.05Å resolution

CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3

Released:
DOI: 10.2210/pdb2xqy/pdb
PDB entry 2xqy coloured by chain, front view.
PDB entry 2xqy coloured by chain, side view.
PDB entry 2xqy coloured by chain, top view.
Source organisms:
Primary publication:
Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody.
Backovic M, DuBois RM, Cockburn JJ, Sharff AJ, Vaney MC, Granzow H, Klupp BG, Bricogne G, Mettenleiter TC, Rey FA
Proc Natl Acad Sci U S A 107 22635-40 (2010)
PMID: 21149698

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210934 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Envelope glycoprotein H Chains: A, E
Molecule details ›
Chains: A, E
Length: 572 amino acids
Theoretical weight: 60.39 KDa
Source organism: Suid alphaherpesvirus 1
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P27416 (Residues: 107-639; Coverage: 81%)
Gene name: gH
Sequence domains: Herpesvirus glycoprotein H C-terminal domain
Structure domains:
A13-D6.3 MONOCLONAL ANTIBODY Chains: G, J
Molecule details ›
Chains: G, J
Length: 261 amino acids
Theoretical weight: 28.1 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
Structure domains: Immunoglobulins
A13-D6.3 MONOCLONAL ANTIBODY Chains: K, L
Molecule details ›
Chains: K, L
Length: 220 amino acids
Theoretical weight: 24.28 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 82.31Å b: 100.63Å c: 161.83Å
α: 90° β: 94.02° γ: 90°
R-values:
R R work R free
0.189 0.188 0.205
Expression system: Drosophila melanogaster

Quick links

Citations

14 review citations

Fusing structure and function: a structural view of the herpesvirus entry machinery.
Connolly et al. (2011)
13 more

12 mentions without citation

Herpes virus fusion and entry: a story with many characters.
Eisenberg et al. (2012)
11 more