Structure analysis

Structure of Nek2 bound to aminopyrazine compound 15

X-ray diffraction
2.001Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 13300 Å2
Buried surface area: 1400 Å2
Dissociation area: 450 Å2
Dissociation energy (ΔGdiss): 3 kcal/mol
Dissociation entropy (TΔSdiss): 5 kcal/mol
Interface energy (ΔGint): -46 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 279 amino acids
Theoretical weight: 32.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51955 (Residues: 1-271; Coverage: 61%)
Gene names: NEK2, NEK2A, NLK1
Pfam: Protein kinase domain
InterPro:
CATH:

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