› 2xik

X-ray diffraction
1.97Å resolution

Structure of Human YSK1 (Yeast Sps1-Ste20-related Kinase 1)

Released:
DOI: 10.2210/pdb2xik/pdb
PDB entry 2xik coloured by chain, front view.
PDB entry 2xik coloured by chain, side view.
PDB entry 2xik coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Muniz JRC, Rellos P, Ugochukwu E, Vollmar M, Allerston C, Chaikuad A, Savitsky P, Berridge G, Brenner B, Elkins JM, Daga N, Gileadi O, Mahajan P, Shrestha B, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126324 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 25 Chain: A
Molecule details ›
Chain: A
Length: 294 amino acids
Theoretical weight: 33.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00506 (Residues: 1-293; Coverage: 69%)
Gene names: SOK1, STK25, YSK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand J60 1 x J60
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 57.08Å b: 48.56Å c: 67.57Å
α: 90° β: 113.78° γ: 90°
R-values:
R R work R free
0.191 0.188 0.233
Expression system: Escherichia coli BL21(DE3)

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