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Structure of the D-Erythrose-4-Phosphate Dehydrogenase from E. coli in complex with a NAD cofactor analog (3-Chloroacetyl adenine pyridine dinucleotide) and sulfate anion

X-ray diffraction
2.95Å resolution
PDB entry 2xf8 coloured by chain, front view.
PDB entry 2xf8 coloured by chain, side view.
PDB entry 2xf8 coloured by chain, top view.
Source organism: Escherichia coli K-12
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: D-erythrose-4-phosphate dehydrogenase
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Multimeric state: homo tetramer
Accessible surface area: 44817.95 Å2
Buried surface area: 12979.96 Å2
Dissociation area: 2,199.41 Å2
Dissociation energy (ΔGdiss): 13.82 kcal/mol
Dissociation entropy (TΔSdiss): 15.38 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-141865
Assembly 2
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Assembly Name: D-erythrose-4-phosphate dehydrogenase
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Multimeric state: homo tetramer
Accessible surface area: 45114.84 Å2
Buried surface area: 12948.89 Å2
Dissociation area: 2,203.58 Å2
Dissociation energy (ΔGdiss): 11.28 kcal/mol
Dissociation entropy (TΔSdiss): 15.39 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-141865
Assembly 3
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Assembly Name: D-erythrose-4-phosphate dehydrogenase
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Multimeric state: homo tetramer
Accessible surface area: 45462.05 Å2
Buried surface area: 12768.37 Å2
Dissociation area: 2,132.07 Å2
Dissociation energy (ΔGdiss): 11.19 kcal/mol
Dissociation entropy (TΔSdiss): 15.37 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-141865
Assembly 4
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Assembly Name: D-erythrose-4-phosphate dehydrogenase
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Multimeric state: homo tetramer
Accessible surface area: 45792.59 Å2
Buried surface area: 12735.7 Å2
Dissociation area: 2,082.09 Å2
Dissociation energy (ΔGdiss): 10.9 kcal/mol
Dissociation entropy (TΔSdiss): 15.36 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-141865

Macromolecules

D-erythrose-4-phosphate dehydrogenase
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 338 amino acids
Theoretical weight: 37.22 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P0A9B6 (Residues: 2-339; Coverage: 100%)
Gene names: JW2894, b2927, epd, gapB
Pfam:
InterPro:
CATH:
D-erythrose-4-phosphate dehydrogenase in PDB entry 2xf8, assembly 1, front view.
D-erythrose-4-phosphate dehydrogenase in PDB entry 2xf8, assembly 1, side view.
D-erythrose-4-phosphate dehydrogenase in PDB entry 2xf8, assembly 1, top view.
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