› 2xer

X-ray diffraction
2.95Å resolution

Human PatL1 C-terminal domain (loop variant with sulfates)

Released:
DOI: 10.2210/pdb2xer/pdb
PDB entry 2xer coloured by chain, front view.
PDB entry 2xer coloured by chain, side view.
PDB entry 2xer coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.
Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O, Izaurralde E
EMBO J 29 2368-80 (2010)
PMID: 20543818

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183161 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein PAT1 homolog 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 248 amino acids
Theoretical weight: 28.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q86TB9 (Residues: 517-767; Coverage: 32%)
Gene names: OK/KNS-cl.5, PATL1
Sequence domains: Topoisomerase II-associated protein PAT1

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Unit cell:
a: 61Å b: 100.1Å c: 141.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.247 0.289
Expression system: Escherichia coli K-12

Quick links

Citations

8 review citations

The role of disordered protein regions in the assembly of decapping complexes and RNP granules.
Jonas et al. (2013)
7 more

1 mention without citation

The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.
Braun et al. (2010)