2x95

X-ray diffraction
1.96Å resolution

Crystal structure of AnCE-lisinopril-tryptophan analogue, lisW-S complex

Released:

Function and Biology Details

Reaction catalysed:
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Angiotensin-converting enzyme Chain: A
Molecule details ›
Chain: A
Length: 599 amino acids
Theoretical weight: 69.24 KDa
Source organism: Drosophila melanogaster
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: Q10714 (Residues: 17-615; Coverage: 100%)
Gene names: Ance, CG8827, Race
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: R3
Unit cell:
a: 172.636Å b: 172.636Å c: 102.413Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.194 0.216
Expression system: Komagataella phaffii GS115