2x7n

Electron Microscopy
11.8Å resolution

Mechanism of eIF6s anti-association activity

Released:
Source organism: Saccharomyces cerevisiae
Primary publication:
Mechanism of eIF6-mediated inhibition of ribosomal subunit joining.
J. Biol. Chem. 285 14848-51 (2010)
PMID: 20356839
Related structures: EMD-1705

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
3 distinct polypeptide molecules
1 distinct RNA molecule
Macromolecules (4 distinct):
Eukaryotic translation initiation factor 6 Chain: B
Molecule details ›
Chain: B
Length: 224 amino acids
Theoretical weight: 24.16 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q12522 (Residues: 1-224; Coverage: 91%)
Gene names: CDC95, LPZ15C, TIF6, YPR016C
Sequence domains: eIF-6 family
60S ribosomal protein L23-A Chain: C
Molecule details ›
Chain: C
Length: 132 amino acids
Theoretical weight: 14.05 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P0CX41 (Residues: 6-137; Coverage: 96%)
Gene names: RPL17A, RPL17AA, RPL23A, YBL0713, YBL087C
Sequence domains: Ribosomal protein L14p/L23e
60S ribosomal protein L24-A Chain: D
Molecule details ›
Chain: D
Length: 56 amino acids
Theoretical weight: 6.55 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P04449 (Residues: 1-56; Coverage: 36%)
Gene names: RP29, RPL24A, RPL30A, YGL031C
SARCIN-RICIN LOOP Chain: A
Molecule details ›
Chain: A
Length: 28 nucleotides
Theoretical weight: 9.04 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 11.8Å
Relevant EMDB volumes: EMD-1705