X-ray diffraction
2.6Å resolution

X-ray structure of cyp51 from trypanosoma brucei in complex with posaconazole in two different conformations

Source organism: Trypanosoma brucei
Entry authors: Chen C-K, Leung SSF, Guilbert C, Jacobson M, McKerrow JH, Podust LM

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Lanosterol 14-alpha-demethylase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 475 amino acids
Theoretical weight: 53.8 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli
  • Canonical: Q385E8 (Residues: 22-481; Coverage: 96%)
Gene name: Tb11.02.4080
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

Cofactor: Ligand HEM 4 x HEM
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: C2
Unit cell:
a: 199.892Å b: 114.527Å c: 138.087Å
α: 90° β: 131.83° γ: 90°
R R work R free
0.195 0.191 0.264
Expression system: Escherichia coli