› › Function and Biology

Structure of the Streptococcus pyogenes family GH38 alpha-mannosidase

Source organism: Streptococcus pyogenes M1 GAS
Biochemical function: metal ion binding
Biological process: oligosaccharide catabolic process
Cellular component: not assigned

Quick links

EC 3.2.1.24: Alpha-mannosidase

Reaction catalysed:
Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides
Systematic name:
Alpha-D-mannoside mannohydrolase
Alternative Name(s):
  • 1,2-alpha-D-mannosidase
  • 1,2-alpha-mannosidase
  • Alpha-D-mannopyranosidase
  • Alpha-D-mannosidase
  • Exo-alpha-mannosidase
  • p-nitrophenyl-alpha-mannosidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF17677
Domain description: Glycosyl hydrolases family 38 C-terminal beta sandwich domain
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
The deposited structure of PDB entry 2wyh contains 2 copies of Pfam domain PF17677 (Glycosyl hydrolases family 38 C-terminal beta sandwich domain) in Glycoside hydrolase family 38 central domain-containing protein. Showing 1 copy in chain A.

PF07748
Domain description: Glycosyl hydrolases family 38 C-terminal domain
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
The deposited structure of PDB entry 2wyh contains 2 copies of Pfam domain PF07748 (Glycosyl hydrolases family 38 C-terminal domain) in Glycoside hydrolase family 38 central domain-containing protein. Showing 1 copy in chain A.

PF18438
Domain description: Glycosyl hydrolases family 38 C-terminal domain 1
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
The deposited structure of PDB entry 2wyh contains 2 copies of Pfam domain PF18438 (Glycosyl hydrolases family 38 C-terminal domain 1) in Glycoside hydrolase family 38 central domain-containing protein. Showing 1 copy in chain A.

PF09261
Domain description: Alpha mannosidase middle domain
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
The deposited structure of PDB entry 2wyh contains 2 copies of Pfam domain PF09261 (Alpha mannosidase middle domain) in Glycoside hydrolase family 38 central domain-containing protein. Showing 1 copy in chain A.

PF01074
Domain description: Glycosyl hydrolases family 38 N-terminal domain
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
The deposited structure of PDB entry 2wyh contains 2 copies of Pfam domain PF01074 (Glycosyl hydrolases family 38 N-terminal domain) in Glycoside hydrolase family 38 central domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015341
Domain description: Glycoside hydrolase family 38, central domain
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
IPR041147
Domain description: Glycosyl hydrolases family 38, C-terminal beta sandwich domain
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
IPR011682
Domain description: Glycosyl hydrolase family 38, C-terminal
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
IPR041509
Domain description: Glycosyl hydrolases 38, beta-1 domain
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
IPR011013
Domain description: Galactose mutarotase-like domain superfamily
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
IPR028995
Domain description: Glycoside hydrolase families 57/38, central domain superfamily
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
IPR037094
Domain description: Glycoside hydrolase family 38, central domain superfamily
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
IPR000602
Domain description: Glycoside hydrolase family 38, N-terminal domain
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
IPR011330
Domain description: Glycoside hydrolase/deacetylase, beta/alpha-barrel
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
IPR027291
Domain description: Glycoside hydrolase 38, N-terminal domain superfamily
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein

Structure domains

CATH CATH domains
2.60.40.2210
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
The deposited structure of PDB entry 2wyh contains 2 copies of CATH domain 2.60.40.2210 (Immunoglobulin-like) in Glycoside hydrolase family 38 central domain-containing protein. Showing 1 copy in chain A.
3.40.50.11160
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
The deposited structure of PDB entry 2wyh contains 2 copies of CATH domain 3.40.50.11160 (Rossmann fold) in Glycoside hydrolase family 38 central domain-containing protein. Showing 1 copy in chain A.
2.60.40.2220
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
The deposited structure of PDB entry 2wyh contains 2 copies of CATH domain 2.60.40.2220 (Immunoglobulin-like) in Glycoside hydrolase family 38 central domain-containing protein. Showing 1 copy in chain A.
2.70.98.30
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: Beta-galactosidase; Chain A, domain 5
Homology: Golgi alpha-mannosidase II; domain 4
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
The deposited structure of PDB entry 2wyh contains 2 copies of CATH domain 2.70.98.30 (Beta-galactosidase; Chain A, domain 5) in Glycoside hydrolase family 38 central domain-containing protein. Showing 1 copy in chain A.
1.20.1270.50
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Substrate Binding Domain Of Dnak; Chain:A; Domain 2
Homology: Glycoside hydrolase family 38, central domain
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
The deposited structure of PDB entry 2wyh contains 2 copies of CATH domain 1.20.1270.50 (Substrate Binding Domain Of Dnak; Chain:A; Domain 2) in Glycoside hydrolase family 38 central domain-containing protein. Showing 1 copy in chain A.
1.10.1240.90
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1
Homology: Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1
Occurring in:
  1. Glycoside hydrolase family 38 central domain-containing protein
The deposited structure of PDB entry 2wyh contains 2 copies of CATH domain 1.10.1240.90 (Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1) in Glycoside hydrolase family 38 central domain-containing protein. Showing 1 copy in chain A.

Quick links