2wxp

X-ray diffraction
2.3Å resolution

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with GDC-0941.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Chain: A

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 142.72Å b: 64.04Å c: 117.74Å
α: 90° β: 103.62° γ: 90°
R-values:
R R work R free
0.222 0.22 0.279
Expression system: Spodoptera frugiperda