Function and Biology Details
Reactions catalysed:
[a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).]
[a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) +ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).]
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- Phosphoinositide 3-kinase, accessory (PIK) domain
- C2 phosphatidylinositol 3-kinase-type domain
- Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
- Phosphatidylinositol 3-/4-kinase, conserved site
- C2 domain superfamily
- Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
- Protein kinase-like domain superfamily
5 more domains
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Molecule details ›
Chain: A
Length: 940 amino acids
Theoretical weight: 107.82 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 940 amino acids
Theoretical weight: 107.82 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
O35904 (Residues: 106-507, 508-1043; Coverage: 90%)
Sequence domains:
- PI3-kinase family, ras-binding domain
- Phosphoinositide 3-kinase C2
- Phosphoinositide 3-kinase family, accessory domain (PIK domain)
- Phosphatidylinositol 3- and 4-kinase
