X-ray diffraction
2.4Å resolution

TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P21

Source organisms:
Primary publication:
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.
Nat. Struct. Mol. Biol. 16 1328-30 (2009)
PMID: 19935683

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ubiquitin Chains: A, B, E, F
Molecule details ›
Chains: A, B, E, F
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Bos taurus
Expression system: Not provided
  • Canonical: P0CH28 (Residues: 609-684; Coverage: 11%)
Gene name: UBC
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 Chains: C, G
Molecule details ›
Chains: C, G
Length: 31 amino acids
Theoretical weight: 3.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9NYJ8 (Residues: 663-693; Coverage: 5%)
Gene names: KIAA0733, MAP3K7IP2, TAB2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 55.39Å b: 73.62Å c: 59.25Å
α: 90° β: 105.91° γ: 90°
R R work R free
0.177 0.174 0.236
Expression systems:
  • Not provided
  • Escherichia coli