X-ray diffraction
2.25Å resolution

Crystal Structure of the Human CLK3 in complex with V25


Function and Biology Details

Reaction catalysed:
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Dual specificity protein kinase CLK3 Chain: A
Molecule details ›
Chain: A
Length: 381 amino acids
Theoretical weight: 44.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P49761 (Residues: 254-264, 265-632; Coverage: 59%)
Gene name: CLK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 87.87Å b: 62.2Å c: 75.37Å
α: 90° β: 97.97° γ: 90°
R R work R free
0.193 0.19 0.246
Expression system: Escherichia coli BL21(DE3)