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The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the Arabidopsis thaliana protein MFP2.

Arent S, Christensen CE, Pye VE, Nørgaard A, Henriksen A
J Biol Chem 285 24066-77 (2010)
Cited: 25 times
EuropePMC logo PMID: 20463021

Abstract

Plant fatty acids can be completely degraded within the peroxisomes. Fatty acid degradation plays a role in several plant processes including plant hormone synthesis and seed germination. Two multifunctional peroxisomal isozymes, MFP2 and AIM1, both with 2-trans-enoyl-CoA hydratase and l-3-hydroxyacyl-CoA dehydrogenase activities, function in mouse ear cress (Arabidopsis thaliana) peroxisomal beta-oxidation, where fatty acids are degraded by the sequential removal of two carbon units. A deficiency in either of the two isozymes gives rise to a different phenotype; the biochemical and molecular background for these differences is not known. Structure determination of Arabidopsis MFP2 revealed that plant peroxisomal MFPs can be grouped into two families, as defined by a specific pattern of amino acid residues in the flexible loop of the acyl-binding pocket of the 2-trans-enoyl-CoA hydratase domain. This could explain the differences in substrate preferences and specific biological functions of the two isozymes. The in vitro substrate preference profiles illustrate that the Arabidopsis AIM1 hydratase has a preference for short chain acyl-CoAs compared with the Arabidopsis MFP2 hydratase. Remarkably, neither of the two was able to catabolize enoyl-CoA substrates longer than 14 carbon atoms efficiently, suggesting the existence of an uncharacterized long chain enoyl-CoA hydratase in Arabidopsis peroxisomes.

Articles - 2wtb mentioned but not cited (2)

  1. The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the Arabidopsis thaliana protein MFP2. Arent S, Christensen CE, Pye VE, Nørgaard A, Henriksen A. J Biol Chem 285 24066-24077 (2010)
  2. Catalytic site identification--a web server to identify catalytic site structural matches throughout PDB. Kirshner DA, Nilmeier JP, Lightstone FC. Nucleic Acids Res 41 W256-65 (2013)


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  1. Plant peroxisomes: biogenesis and function. Hu J, Baker A, Bartel B, Linka N, Mullen RT, Reumann S, Zolman BK. Plant Cell 24 2279-2303 (2012)
  2. Salicylic Acid Biosynthesis in Plants. Lefevere H, Bauters L, Gheysen G. Front Plant Sci 11 338 (2020)
  3. Metabolic control of redox and redox control of metabolism in plants. Geigenberger P, Fernie AR. Antioxid Redox Signal 21 1389-1421 (2014)

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  2. ABNORMAL INFLORESCENCE MERISTEM1 Functions in Salicylic Acid Biosynthesis to Maintain Proper Reactive Oxygen Species Levels for Root Meristem Activity in Rice. Xu L, Zhao H, Ruan W, Deng M, Wang F, Peng J, Luo J, Chen Z, Yi K. Plant Cell 29 560-574 (2017)
  3. Different stress responsive strategies to drought and heat in two durum wheat cultivars with contrasting water use efficiency. Aprile A, Havlickova L, Panna R, Marè C, Borrelli GM, Marone D, Perrotta C, Rampino P, De Bellis L, Curn V, Mastrangelo AM, Rizza F, Cattivelli L. BMC Genomics 14 821 (2013)
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  5. Defining the plant peroxisomal proteome: from Arabidopsis to rice. Kaur N, Hu J. Front Plant Sci 2 103 (2011)
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  12. Diurnal dynamics of the Arabidopsis rosette proteome and phosphoproteome. Uhrig RG, Echevarría-Zomeño S, Schlapfer P, Grossmann J, Roschitzki B, Koerber N, Fiorani F, Gruissem W. Plant Cell Environ 44 821-841 (2021)
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  16. An integrated analysis of the rice transcriptome and lipidome reveals lipid metabolism plays a central role in rice cold tolerance. Liu H, Xin W, Wang Y, Zhang D, Wang J, Zheng H, Yang L, Nie S, Zou D. BMC Plant Biol 22 91 (2022)
  17. Sequence analysis and structure prediction of enoyl-CoA hydratase from Avicennia marina: implication of various amino acid residues on substrate-enzyme interactions. Jabeen U, Salim A. Phytochemistry 94 36-44 (2013)
  18. Chemical Genetics Approach Identifies Abnormal Inflorescence Meristem 1 as a Putative Target of a Novel Sulfonamide That Protects Catalase2-Deficient Arabidopsis against Photorespiratory Stress. van der Meer T, Verlee A, Willems P, Impens F, Gevaert K, Testerink C, Stevens CV, Van Breusegem F, Kerchev P. Cells 9 E2026 (2020)
  19. Integrating genomic and multiomic data for Angelica sinensis provides insights into the evolution and biosynthesis of pharmaceutically bioactive compounds. Li S, Chiu TY, Jin X, Cao D, Xu M, Zhu M, Zhou Q, Liu C, Zong Y, Wang S, Yu K, Zhang F, Bai M, Liu G, Liang Y, Zhang C, Simonsen HT, Zhao J, Liu B, Zhao S. Commun Biol 6 1198 (2023)
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Related citations provided by authors (1)

  1. The Arabidopsis thaliana multifunctional protein gene (MFP2) of peroxisomal beta-oxidation is essential for seedling establishment.. Rylott EL, Eastmond PJ, Gilday AD, Slocombe SP, Larson TR, Baker A, Graham IA Plant J 45 930-41 (2006)

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