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Semi-synthetic analogue of human insulin ProB26-DTI in monomer form

X-ray diffraction
1.9Å resolution
PDB entry 2ws4 coloured by chain, front view.
PDB entry 2ws4 coloured by chain, side view.
PDB entry 2ws4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin B chain
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Multimeric state: hetero tetramer
Accessible surface area: 5472.79 Å2
Buried surface area: 3840.19 Å2
Dissociation area: 715.95 Å2
Dissociation energy (ΔGdiss): 6.31 kcal/mol
Dissociation entropy (TΔSdiss): 9.44 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134210

Macromolecules

Insulin A chain
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
Insulin A chain in PDB entry 2ws4, assembly 1, front view.
Insulin A chain in PDB entry 2ws4, assembly 1, side view.
Insulin A chain in PDB entry 2ws4, assembly 1, top view.
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Insulin B chain
Chain: B
Length: 26 amino acids
Theoretical weight: 2.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-50; Coverage: 30%)
Gene name: INS
InterPro:
Insulin B chain in PDB entry 2ws4, assembly 1, front view.
Insulin B chain in PDB entry 2ws4, assembly 1, side view.
Insulin B chain in PDB entry 2ws4, assembly 1, top view.
Molecule details ›

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