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Complex of TTR and RBP4 and Oleic Acid

X-ray diffraction
2.85Å resolution
PDB entry 2wqa coloured by chain, front view.
PDB entry 2wqa coloured by chain, side view.
PDB entry 2wqa coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Retinol-binding protein 4 and Transthyretin
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Multimeric state: hetero hexamer
Accessible surface area: 36120.85 Å2
Buried surface area: 13050.17 Å2
Dissociation area: 1,707.76 Å2
Dissociation energy (ΔGdiss): -5.06 kcal/mol
Dissociation entropy (TΔSdiss): 25.36 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136149

Macromolecules

Transthyretin
Chains: A, B, C, D
Length: 129 amino acids
Theoretical weight: 13.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Pfam: HIUase/Transthyretin family
InterPro:
CATH: Transthyretin/hydroxyisourate hydrolase domain
Transthyretin in PDB entry 2wqa, assembly 1, front view.
Transthyretin in PDB entry 2wqa, assembly 1, side view.
Transthyretin in PDB entry 2wqa, assembly 1, top view.
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Retinol-binding protein 4
Chains: E, F
Length: 177 amino acids
Theoretical weight: 20.28 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P02753 (Residues: 19-194; Coverage: 96%)
Gene names: PRO2222, RBP4
Pfam: Lipocalin / cytosolic fatty-acid binding protein family
InterPro:
CATH: Lipocalin
Retinol-binding protein 4 in PDB entry 2wqa, assembly 1, front view.
Retinol-binding protein 4 in PDB entry 2wqa, assembly 1, side view.
Retinol-binding protein 4 in PDB entry 2wqa, assembly 1, top view.
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