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Crystal structures of Holliday junction resolvases from Archaeoglobus fulgidus bound to DNA substrate

Source organisms:
Biochemical function: metal ion binding
Biological process: DNA damage response
Cellular component: not assigned

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EC 3.1.21.10: Crossover junction endodeoxyribonuclease

Reaction catalysed:
Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)
Systematic name:
-
Alternative Name(s):
  • Crossover junction endoribonuclease
  • Cruciform-cutting endonuclease
  • Endo X3
  • Endonuclease RuvC
  • Endonuclease VII
  • Endonuclease X3
  • Hje endonuclease
  • Holliday junction endonuclease CCE1
  • Holliday junction nuclease
  • Holliday junction resolvase
  • Holliday junction-cleaving endonuclease
  • Holliday junction-resolving endoribonuclease
  • Resolving enzyme CCE1
  • RusA Holliday junction resolvase
  • RusA endonuclease
  • RuvC endonuclease
  • SpCCe1 Holliday junction resolvase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01870
Domain description: Archaeal holliday junction resolvase (hjc)
Occurring in:
  1. Crossover junction endodeoxyribonuclease Hjc
The deposited structure of PDB entry 2wiz contains 2 copies of Pfam domain PF01870 (Archaeal holliday junction resolvase (hjc)) in Crossover junction endodeoxyribonuclease Hjc. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR014428
Domain description: Crossover junction endodeoxyribonuclease Hjc, archaeal
Occurring in:
  1. Crossover junction endodeoxyribonuclease Hjc
IPR002732
Domain description: Holliday junction resolvase Hjc
Occurring in:
  1. Crossover junction endodeoxyribonuclease Hjc
IPR011335
Domain description: Restriction endonuclease type II-like
Occurring in:
  1. Crossover junction endodeoxyribonuclease Hjc
IPR011856
Domain description: tRNA endonuclease-like domain superfamily
Occurring in:
  1. Crossover junction endodeoxyribonuclease Hjc

Structure domain

CATH CATH domain
3.40.1350.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Trna Endonuclease; Chain: A, domain 1
Homology: Trna Endonuclease; Chain: A, domain 1
Occurring in:
  1. Crossover junction endodeoxyribonuclease Hjc
The deposited structure of PDB entry 2wiz contains 2 copies of CATH domain 3.40.1350.10 (Trna Endonuclease; Chain: A, domain 1) in Crossover junction endodeoxyribonuclease Hjc. Showing 1 copy in chain A.

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