Structure analysis

Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines

X-ray diffraction
1.58Å resolution
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 16000 Å2
Buried surface area: 2400 Å2
Dissociation area: 300 Å2
Dissociation energy (ΔGdiss): -6 kcal/mol
Dissociation entropy (TΔSdiss): 3 kcal/mol
Interface energy (ΔGint): -20 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 413 amino acids
Theoretical weight: 45.71 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WPN5 (Residues: 2-405; Coverage: 100%)
Gene names: MTCY50.26, Rv1256c, cyp130
Pfam: Cytochrome P450
InterPro:
CATH: Cytochrome P450

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