PDBe 2wh6

X-ray diffraction
1.5Å resolution

Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator BHRF1 Chain: A
Molecule details ›
Chain: A
Length: 173 amino acids
Theoretical weight: 19.85 KDa
Source organism: Epstein-barr virus strain ag876
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0C6Z1 (Residues: 1-160; Coverage: 84%)
Gene name: BHRF1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Bcl-2-like protein 11 Chain: B
Molecule details ›
Chain: B
Length: 26 amino acids
Theoretical weight: 3.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43521 (Residues: 141-166; Coverage: 13%)
Gene names: BCL2L11, BIM

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3221
Unit cell:
a: 62.747Å b: 62.747Å c: 92.383Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.198 0.205
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided