› 2wbr

Solution NMR

The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing

Released:
DOI: 10.2210/pdb2wbr/pdb
PDB entry 2wbr coloured by chain, ensemble of 24 models, front view.
PDB entry 2wbr coloured by chain, ensemble of 24 models, side view.
PDB entry 2wbr coloured by chain, ensemble of 24 models, top view.
Source organism: Drosophila melanogaster
Primary publication:
The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing.
Eulalio A, Tritschler F, Büttner R, Weichenrieder O, Izaurralde E, Truffault V
Nucleic Acids Res 37 2974-83 (2009)
PMID: 19295135

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186110 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Gawky Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 9.83 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8SY33 (Residues: 1110-1198; Coverage: 6%)
Gene names: CG31992, GW182, gw
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: XPLOR
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Regulation of mRNA translation and stability by microRNAs.
Fabian et al. (2010)
11 more

2 mentions without citation

The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing.
Eulalio et al. (2009)
1 more