Structure analysis

Crystal Structure of CDK4 in complex with a D-type cyclin

X-ray diffraction
2.45Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 25900 Å2
Buried surface area: 2300 Å2
Dissociation area: 1,100 Å2
Dissociation energy (ΔGdiss): 5 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -13 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 257 amino acids
Theoretical weight: 29.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24385 (Residues: 16-271; Coverage: 87%)
Gene names: BCL1, CCND1, PRAD1
Pfam: Cyclin, N-terminal domain
InterPro:
CATH: Cyclin-like

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Chain: B
Length: 306 amino acids
Theoretical weight: 34.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11802 (Residues: 1-303; Coverage: 99%)
  • Best match: P11802-2 (Residues: 1-183)
Gene name: CDK4
Pfam: Protein kinase domain
InterPro:
CATH:

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