› 2vzz

X-ray diffraction
2.3Å resolution

Crystal structure of Rv0802c from Mycobacterium tuberculosis in Complex with Succinyl-CoA

Released:
DOI: 10.2210/pdb2vzz/pdb
PDB entry 2vzz coloured by chain, front view.
PDB entry 2vzz coloured by chain, side view.
PDB entry 2vzz coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Rv0802c from Mycobacterium tuberculosis: the first structure of a succinyltransferase with the GNAT fold.
Vetting MW, Errey JC, Blanchard JS
Acta Crystallogr Sect F Struct Biol Cryst Commun 64 978-85 (2008)
PMID: 18997321

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162075 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetyl- and succinyl-CoA transferase Rv0802c Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 218 amino acids
Theoretical weight: 25.02 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WQG7 (Residues: 1-218; Coverage: 100%)
Gene name: Rv0802c
Sequence domains: Acetyltransferase (GNAT) domain
Structure domains: Aminopeptidase

Ligands and Environments

1 bound ligand:
Ligand SCA 4 x SCA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: I222
Unit cell:
a: 113.165Å b: 135.172Å c: 164.077Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.169 0.222
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation.
Favrot et al. (2016)
6 more

4 mentions without citation

Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT).
Salah Ud-Din et al. (2016)
3 more