› 2vt4

X-ray diffraction
2.7Å resolution

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND CYANOPINDOLOL

Released:
DOI: 10.2210/pdb2vt4/pdb
PDB 2vt4 coloured by chain and viewed from the front.
PDB 2vt4 coloured by chain and viewed from the side.
PDB 2vt4 coloured by chain and viewed from the top.
Source organism: Meleagris gallopavo
Entry authors: Warne A, Serrano-Vega MJ, Baker JG, Moukhametzianov R, Edwards PC, Henderson R, Leslie AGW, Tate CG, Schertler GFX

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-1 adrenergic receptor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 313 amino acids
Theoretical weight: 35.75 KDa
Source organism: Meleagris gallopavo
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P07700 (Residues: 31-368; Coverage: 64%)
Gene name: ADRB1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins

Ligands and Environments

4 bound ligands:
Ligand P32 4 x P32
Ligand NA 4 x NA
Ligand SOG 12 x SOG
Ligand D10 2 x D10
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P1
Unit cell:
a: 55.5Å b: 86.8Å c: 95.5Å
α: 67.6° β: 73.3° γ: 85.8°
R-values:
R R work R free
0.215 0.212 0.268
Expression system: Trichoplusia ni

Quick links

Citations

167 review citations

Novel Molecular Targets of Antidepressants.
Jarończyk et al. (2022)
166 more

153 mentions without citation

The Molecular Basis of G Protein-Coupled Receptor Activation.
Weis et al. (2018)
152 more