› 2vsc

X-ray diffraction
1.9Å resolution

Structure of the immunoglobulin-superfamily ectodomain of human CD47

Released:
DOI: 10.2210/pdb2vsc/pdb
PDB 2vsc coloured by chain and viewed from the front.
PDB 2vsc coloured by chain and viewed from the side.
PDB 2vsc coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN
Mol. Cell 31 266-77 (2008)
PMID: 18657508

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukocyte surface antigen CD47 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 127 amino acids
Theoretical weight: 14.52 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q08722 (Residues: 19-136; Coverage: 39%)
Gene names: CD47, MER6
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NAG 12 x NAG
Ligand MG 2 x MG
1 modified residue:
Ligand PCA 4 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2
Unit cell:
a: 201.137Å b: 47.502Å c: 56.811Å
α: 90° β: 99.31° γ: 90°
R-values:
R R work R free
0.219 0.216 0.263
Expression system: Cricetulus griseus

Quick links

Citations

19 review citations

Macrophage checkpoint blockade: results from initial clinical trials, binding analyses, and CD47-SIRPĪ± structure-function.
Jalil et al. (2020)
18 more