X-ray diffraction
1.4Å resolution

Structural analysis of homodimeric staphylococcal aureus virulence factor EsxA


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Type VII secretion system extracellular protein A Chains: A, B
Molecule details ›
Chains: A, B
Length: 97 amino acids
Theoretical weight: 11.19 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli BL21
  • Canonical: Q99WU4 (Residues: 1-97; Coverage: 100%)
Gene names: SAV0282, esxA
Sequence domains: Proteins of 100 residues with WXG
Structure domains: ESAT-6-like

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P1
Unit cell:
a: 25.773Å b: 39.069Å c: 43.029Å
α: 67.41° β: 84.51° γ: 88.76°
R R work R free
0.169 0.166 0.218
Expression system: Escherichia coli BL21