2vq6

X-ray diffraction
2.71Å resolution

Torpedo californica acetylcholinesterase complexed with 2-PAM

Released:
Source organism: Tetronarce californica
Entry authors: Harel M, Silman I, Sussman JL

Function and Biology Details

Reaction catalysed:
Acetylcholine + H(2)O = choline + acetate

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 543 amino acids
Theoretical weight: 61.33 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P04058 (Residues: 22-564; Coverage: 96%)
Gene name: ache
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 113.95Å b: 113.95Å c: 138.05Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.171 0.234