› › Structure analysis

Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorophenyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-yl)methylamine

X-ray diffraction
1.94Å resolution
PDB 2vo0 coloured by chain and viewed from the front.
PDB 2vo0 coloured by chain and viewed from the side.
PDB 2vo0 coloured by chain and viewed from the top.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 16400 Å2
Buried surface area: 4300 Å2
Dissociation area: 1,000 Å2
Dissociation energy (ΔGdiss): 4 kcal/mol
Dissociation entropy (TΔSdiss): 9 kcal/mol
Interface energy (ΔGint): -3 kcal/mol
Symmetry number: 1

Macromolecules

cAMP-dependent protein kinase catalytic subunit alpha
Chain: A
Length: 351 amino acids
Theoretical weight: 40.91 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00517 (Residues: 1-351; Coverage: 100%)
Gene name: PRKACA
Pfam: Protein kinase domain
InterPro:
CATH:
PDB 2vo0 contains 1 copy of cAMP-dependent protein kinase catalytic subunit alpha in assembly 1. This protein is highlighted and viewed from the front.
PDB 2vo0 contains 1 copy of cAMP-dependent protein kinase catalytic subunit alpha in assembly 1. This protein is highlighted and viewed from the side.
PDB 2vo0 contains 1 copy of cAMP-dependent protein kinase catalytic subunit alpha in assembly 1. This protein is highlighted and viewed from the top.
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cAMP-dependent protein kinase inhibitor alpha
Chain: I
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61925 (Residues: 6-25; Coverage: 26%)
Gene names: PKIA, PRKACN1
InterPro: cAMP-dependent protein kinase inhibitor
PDB 2vo0 contains 1 copy of cAMP-dependent protein kinase inhibitor alpha in assembly 1. This protein is highlighted and viewed from the front.
PDB 2vo0 contains 1 copy of cAMP-dependent protein kinase inhibitor alpha in assembly 1. This protein is highlighted and viewed from the side.
PDB 2vo0 contains 1 copy of cAMP-dependent protein kinase inhibitor alpha in assembly 1. This protein is highlighted and viewed from the top.
Molecule details ›

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