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Crystallographic analysis of the intact metal centres [3Fe-4S](1+/0) and [4Fe-4S](2+/1+) in a Zn(2+) -containing ferredoxin.

Frazão C, Aragão D, Coelho R, Leal SS, Gomes CM, Teixeira M, Carrondo MA
FEBS Lett 582 763-7 (2008)
Cited: 9 times
EuropePMC logo PMID: 18258200

Abstract

Detailed structural models of di-cluster seven-iron ferredoxins constitute a valuable resource for folding and stability studies relating the metal cofactors' role in protein stability. The here reported, hemihedric twinned crystal structure at 2.0 A resolution from Acidianus ambivalens ferredoxin, shows an integral 103 residues, physiologically relevant native form composed by a N-terminal extension comprising a His/Asp Zn(2+) site and the ferredoxin (betaalphabeta)(2) core, which harbours intact clusters I and II, a [3Fe-4S](1+/0) and a [4Fe-4S](2+/1+) centres. This is in contrast with the previously available ferredoxin structure from Sulfolofus tokodai, which was obtained from an artificial oxidative conversion with two [3Fe-4S](1+/0) centres and poor definition around cluster II.

Reviews - 2vkr mentioned but not cited (1)

  1. Iron-sulfur world in aerobic and hyperthermoacidophilic archaea Sulfolobus. Iwasaki T. Archaea 2010 842639 (2010)

Articles - 2vkr mentioned but not cited (2)

  1. Ferredoxins as interchangeable redox components in support of MiaB, a radical S-adenosylmethionine methylthiotransferase. Arcinas AJ, Maiocco SJ, Elliott SJ, Silakov A, Booker SJ. Protein Sci 28 267-282 (2019)
  2. Evolutionary Relationships Between Low Potential Ferredoxin and Flavodoxin Electron Carriers. Campbell IJ, Bennett GN, Silberg JJ. Front Energy Res 7 (2019)


Reviews citing this publication (2)

  1. Structural biology of redox partner interactions in P450cam monooxygenase: a fresh look at an old system. Sevrioukova IF, Poulos TL. Arch Biochem Biophys 507 66-74 (2011)
  2. Redox-Sensing Iron-Sulfur Cluster Regulators. Crack JC, Le Brun NE. Antioxid Redox Signal 29 1809-1829 (2018)

Articles citing this publication (4)

  1. Contrasting Health Effects of Bacteroidetes and Firmicutes Lies in Their Genomes: Analysis of P450s, Ferredoxins, and Secondary Metabolite Clusters. Nkosi BVZ, Padayachee T, Gront D, Nelson DR, Syed K. Int J Mol Sci 23 5057 (2022)
  2. Diversification of Ferredoxins across Living Organisms. Nzuza N, Padayachee T, Chen W, Gront D, Nelson DR, Syed K. Curr Issues Mol Biol 43 1374-1390 (2021)
  3. Structure at 1.0 A resolution of a high-potential iron-sulfur protein involved in the aerobic respiratory chain of Rhodothermus marinus. Stelter M, Melo AM, Hreggvidsson S, Saraiva LM, Teixeira M, Archer M. J Biol Inorg Chem 15 303-313 (2010)
  4. Redox-sensing iron-sulfur cluster regulators. Crack JC, Le Brun NE. Antioxid Redox Signal (2017)


Related citations provided by authors (5)

  1. A spectroscopic study of the temperature induced modifications on ferredoxin folding and iron-sulfur moieties.. Todorovic S, Leal SS, Salgueiro CA, Zebger I, Hildebrandt P, Murgida DH, Gomes CM Biochemistry 46 10733-8 (2007)
  2. Studies of the molten globule state of ferredoxin: structural characterization and implications on protein folding and iron-sulfur center assembly.. Leal SS, Gomes CM Proteins 68 606-16 (2007)
  3. Natural domain design: enhanced thermal stability of a zinc-lacking ferredoxin isoform shows that a hydrophobic core efficiently replaces the structural metal site.. Rocha R, Leal SS, Teixeira VH, Regalla M, Huber H, Baptista AM, Soares CM, Gomes CM Biochemistry 45 10376-84 (2006)
  4. ,Di-Cluster, Seven-Iron Ferredoxins from Hyperthermophilic Sulfolobales. Gomes CM, Faria A, Carita JC, Mendes J, Regalla M, Chicau P, Huber H, Stetter KO, Teixeira M J. Biol. Inorg. Chem. 3 499- (1998)
  5. A seven-iron ferredoxin from the thermoacidophilic archaeon Desulfurolobus ambivalens.. Teixeira M, Batista R, Campos AP, Gomes C, Mendes J, Pacheco I, Anemuller S, Hagen WR Eur J Biochem 227 322-7 (1995)

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