› › Structure analysis

Crystal Structure of the MDM2-MDMX RING Domain Heterodimer

X-ray diffraction
2.3Å resolution
PDB entry 2vjf coloured by chain, front view.
PDB entry 2vjf coloured by chain, side view.
PDB entry 2vjf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1
Download    3D Visualisation
Assembly Name: Protein Mdm4 and E3 ubiquitin-protein ligase Mdm2
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 6676.2 Å2
Buried surface area: 2693.89 Å2
Dissociation area: 1,346.94 Å2
Dissociation energy (ΔGdiss): 19.37 kcal/mol
Dissociation entropy (TΔSdiss): 9.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127327
Assembly 2 (preferred)
Download    3D Visualisation
Assembly Name: Protein Mdm4 and E3 ubiquitin-protein ligase Mdm2
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 6712.08 Å2
Buried surface area: 2916.29 Å2
Dissociation area: 1,332.06 Å2
Dissociation energy (ΔGdiss): 18.19 kcal/mol
Dissociation entropy (TΔSdiss): 10.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127327

Macromolecules

E3 ubiquitin-protein ligase Mdm2
Chains: A, C
Length: 64 amino acids
Theoretical weight: 7.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q00987 (Residues: 428-491; Coverage: 13%)
Gene name: MDM2
Pfam: Zinc finger, C3HC4 type (RING finger)
InterPro:
CATH: Zinc/RING finger domain, C3HC4 (zinc finger)
E3 ubiquitin-protein ligase Mdm2 in PDB entry 2vjf, assembly 2, front view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 2vjf, assembly 2, side view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 2vjf, assembly 2, top view.
Molecule details ›

Search similar proteins

Protein Mdm4
Chains: B, D
Length: 63 amino acids
Theoretical weight: 7.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15151 (Residues: 428-490; Coverage: 13%)
Gene names: MDM4, MDMX
Pfam: Zinc finger, C3HC4 type (RING finger)
InterPro:
CATH: Zinc/RING finger domain, C3HC4 (zinc finger)
Protein Mdm4 in PDB entry 2vjf, assembly 2, front view.
Protein Mdm4 in PDB entry 2vjf, assembly 2, side view.
Protein Mdm4 in PDB entry 2vjf, assembly 2, top view.
Molecule details ›

Search similar proteins

Quick links