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Structure of the Symmetric Mad2 Dimer

X-ray diffraction
1.95Å resolution
PDB entry 2vfx coloured by chain, front view.
PDB entry 2vfx coloured by chain, side view.
PDB entry 2vfx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12070.3 Å2
Buried surface area: 832.16 Å2
Dissociation area: 205.27 Å2
Dissociation energy (ΔGdiss): -7.19 kcal/mol
Dissociation entropy (TΔSdiss): 3.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619
Assembly 10
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12288.99 Å2
Buried surface area: 522.35 Å2
Dissociation area: 39.57 Å2
Dissociation energy (ΔGdiss): 4.64 kcal/mol
Dissociation entropy (TΔSdiss): -0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619
Assembly 11
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12406.3 Å2
Buried surface area: 622.34 Å2
Dissociation area: 173.75 Å2
Dissociation energy (ΔGdiss): 0.66 kcal/mol
Dissociation entropy (TΔSdiss): 2.4 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619
Assembly 12
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12248.81 Å2
Buried surface area: 739.51 Å2
Dissociation area: 188.59 Å2
Dissociation energy (ΔGdiss): -8.12 kcal/mol
Dissociation entropy (TΔSdiss): 3.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619
Assembly 2 (preferred)
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12385.72 Å2
Buried surface area: 848.98 Å2
Dissociation area: 169.08 Å2
Dissociation energy (ΔGdiss): 0.68 kcal/mol
Dissociation entropy (TΔSdiss): 2.34 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619
Assembly 3
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12301.69 Å2
Buried surface area: 772.66 Å2
Dissociation area: 172.01 Å2
Dissociation energy (ΔGdiss): 1.35 kcal/mol
Dissociation entropy (TΔSdiss): 2.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619
Assembly 4
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12110.68 Å2
Buried surface area: 533.13 Å2
Dissociation area: 45.16 Å2
Dissociation energy (ΔGdiss): 5.8 kcal/mol
Dissociation entropy (TΔSdiss): -0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619
Assembly 5
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12408.25 Å2
Buried surface area: 971.28 Å2
Dissociation area: 172.42 Å2
Dissociation energy (ΔGdiss): -7.08 kcal/mol
Dissociation entropy (TΔSdiss): 3.09 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619
Assembly 6
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12053.54 Å2
Buried surface area: 641.99 Å2
Dissociation area: 169.74 Å2
Dissociation energy (ΔGdiss): 0.77 kcal/mol
Dissociation entropy (TΔSdiss): 2.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619
Assembly 7
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12388.97 Å2
Buried surface area: 508.14 Å2
Dissociation area: 169.26 Å2
Dissociation energy (ΔGdiss): 0.22 kcal/mol
Dissociation entropy (TΔSdiss): 2.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619
Assembly 8
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12469.09 Å2
Buried surface area: 7.7 Å2
Dissociation area: 3.85 Å2
Dissociation energy (ΔGdiss): -2.29 kcal/mol
Dissociation entropy (TΔSdiss): 2.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619
Assembly 9
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Assembly Name: Mitotic spindle assembly checkpoint protein MAD2A
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Multimeric state: monomeric
Accessible surface area: 12167.92 Å2
Buried surface area: 680.76 Å2
Dissociation area: 127.76 Å2
Dissociation energy (ΔGdiss): -3.6 kcal/mol
Dissociation entropy (TΔSdiss): 1.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171619

Macromolecules

Mitotic spindle assembly checkpoint protein MAD2A
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 206 amino acids
Theoretical weight: 23.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: Q13257 (Residues: 1-205)
Gene names: MAD2, MAD2L1
Mitotic spindle assembly checkpoint protein MAD2A in PDB entry 2vfx, assembly 2, front view.
Mitotic spindle assembly checkpoint protein MAD2A in PDB entry 2vfx, assembly 2, side view.
Mitotic spindle assembly checkpoint protein MAD2A in PDB entry 2vfx, assembly 2, top view.
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