X-ray diffraction
2.8Å resolution

Structure of Human Myotonic Dystrophy Protein Kinase in Complex with the Bisindoylmaleide inhibitor BIM VIII

Source organism: Homo sapiens
Entry authors: Pike ACW, Amos A, Elkins J, Bullock A, Guo K, Fedorov O, Bunkoczi G, Filippakopoulos P, Pilka ES, Ugochukwu E, Umeano C, Niesen F, Sundstrom M, Weigelt J, Edwards A, Arrowsmith CH, von Delft F, Knapp S

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Myotonin-protein kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 412 amino acids
Theoretical weight: 46.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q09013 (Residues: 10-420; Coverage: 65%)
Gene names: DM1PK, DMPK, MDPK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 122.599Å b: 122.599Å c: 134.278Å
α: 90° β: 90° γ: 120°
R R work R free
0.198 0.196 0.244
Expression system: Escherichia coli BL21(DE3)