Function and Biology

Mouse Profilin IIa in complex with the proline-rich domain of VASP

Source organism: Mus musculus
Biochemical function: ATP hydrolysis activity
Biological process: regulation of synaptic vesicle exocytosis
Cellular component: glutamatergic synapse

Sequence family

Pfam Protein family (Pfam)
PF00235
Domain description: Profilin
Occurring in:
  1. Profilin-2
The deposited structure of PDB entry 2v8c contains 1 copy of Pfam domain PF00235 (Profilin) in Profilin-2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005454
Domain description: Profilin1/2/3, vertebrate
Occurring in:
  1. Profilin-2
IPR005455
Domain description: Profilin, eukaryotic type
Occurring in:
  1. Profilin-2
IPR036140
Domain description: Profilin superfamily
Occurring in:
  1. Profilin-2
IPR027310
Domain description: Profilin conserved site
Occurring in:
  1. Profilin-2

Structure domain

CATH CATH domain
3.30.450.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta-Lactamase
Homology: Dynein light chain 2a, cytoplasmic
Occurring in:
  1. Profilin-2
The deposited structure of PDB entry 2v8c contains 1 copy of CATH domain 3.30.450.30 (Beta-Lactamase) in Profilin-2. Showing 1 copy in chain A.