› 2v8c

X-ray diffraction
1.98Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159737 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Profilin-2 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 15.05 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JJV2 (Residues: 1-140; Coverage: 100%)
Gene name: Pfn2
Sequence domains: Profilin
Structure domains: Dynein light chain 2a, cytoplasmic
Vasodilator-stimulated phosphoprotein Chain: C
Molecule details ›
Chain: C
Length: 20 amino acids
Theoretical weight: 1.82 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P70460 (Residues: 165-184; Coverage: 5%)
Gene name: Vasp

Ligands and Environments

4 bound ligands:
Ligand SO4 3 x SO4
Ligand IPA 2 x IPA
Ligand NA 1 x NA
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 43.73Å b: 47.09Å c: 68.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.146 0.145 0.181
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

11 review citations

Unleashing formins to remodel the actin and microtubule cytoskeletons.
Chesarone et al. (2010)
10 more

6 mentions without citation

Profilin Isoforms in Health and Disease - All the Same but Different.
Murk et al. (2021)
5 more