2v5r

X-ray diffraction
3Å resolution

Structural basis for Dscam isoform specificity

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Down syndrome cell adhesion molecule 1, isoform BE Chains: A, B
Molecule details ›
Chains: A, B
Length: 391 amino acids
Theoretical weight: 43.48 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q0E9K4 (Residues: 36-189, 190-424; Coverage: 19%)
Gene names: 43Bc, CG17800, CT39257, DSCAM, DScam, DmDscam, Dm_2R:13579, Dm_2R:13612, Dmel\CG17800, Dmel_CG17800, DsCam, Dscam, Dscam-hv, Dscam1, Dsm, Neu1, dScam, dscam, dscam1, l(2)05518, l(2)43Bc, p270
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 277.781Å b: 70.548Å c: 72.771Å
α: 90° β: 105.13° γ: 90°
R-values:
R R work R free
0.271 0.271 0.303
Expression system: Spodoptera frugiperda