› 2v41

X-ray diffraction
2.4Å resolution

Crystal Structure of the C45S mutant of the Peroxiredoxin 6 of Arenicola Marina. Orthorhombic form

Released:
DOI: 10.2210/pdb2v41/pdb
PDB 2v41 coloured by chain and viewed from the front.
PDB 2v41 coloured by chain and viewed from the side.
PDB 2v41 coloured by chain and viewed from the top.
Source organism: Arenicola marina
Primary publication:
The crystal structure of the C45S mutant of annelid Arenicola marina peroxiredoxin 6 supports its assignment to the mechanistically typical 2-Cys subfamily without any formation of toroid-shaped decamers.
Smeets A, Loumaye E, Clippe A, Rees JF, Knoops B, Declercq JP
Protein Sci. 17 700-10 (2008)
PMID: 18359859

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin domain-containing protein Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 233 amino acids
Theoretical weight: 25.81 KDa
Source organism: Arenicola marina
Expression system: Escherichia coli
UniProt:
  • Canonical: Q1AN22 (Residues: 1-220; Coverage: 100%)
Gene name: Prdx6
Sequence domains: AhpC/TSA family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand BEZ 8 x BEZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P212121
Unit cell:
a: 77.11Å b: 111.156Å c: 229.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.239
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
Hall et al. (2011)
1 more

2 mentions without citation

Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization.
Hall et al. (2010)
1 more