PDBe 2v40

X-ray diffraction
1.9Å resolution

Human Adenylosuccinate synthetase isozyme 2 in complex with GDP

Released:
Source organism: Homo sapiens
Entry authors: Welin M, Moche M, Arrowsmith C, Berglund H, Busam R, Collins R, Dahlgren LG, Edwards A, Flodin S, Flores A, Graslund S, Hammarstrom M, Hallberg BM, Holmberg-Schiavone L, Johansson I, Kallas A, Karlberg T, Kotenyova T, Lehtio L, Nyman T, Ogg D, Persson C, Sagemark J, Stenmark P, Sundstrom M, Thorsell AG, Tresaugues L, van den Berg S, Weigelt J, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylosuccinate synthetase isozyme 2 Chain: A
Molecule details ›
Chain: A
Length: 459 amino acids
Theoretical weight: 50.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30520 (Residues: 21-456; Coverage: 96%)
Gene names: ADSS, ADSS2
Sequence domains: Adenylosuccinate synthetase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P6322
Unit cell:
a: 155.41Å b: 155.41Å c: 82.12Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.166 0.165 0.198
Expression system: Escherichia coli BL21(DE3)