Structure analysis

Crystal structure of econazole-bound CYP130 from Mycobacterium tuberculosis

X-ray diffraction
3Å resolution
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 54800 Å2
Buried surface area: 23200 Å2
Dissociation area: 1,600 Å2
Dissociation energy (ΔGdiss): 6 kcal/mol
Dissociation entropy (TΔSdiss): 15 kcal/mol
Interface energy (ΔGint): -234 kcal/mol
Symmetry number: 2

Macromolecules

Chains: A, B
Length: 414 amino acids
Theoretical weight: 45.84 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WPN5 (Residues: 1-405; Coverage: 100%)
Gene names: MTCY50.26, Rv1256c, cyp130
Pfam: Cytochrome P450
InterPro:
CATH: Cytochrome P450

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