X-ray diffraction
3Å resolution

Crystal structure of econazole-bound CYP130 from Mycobacterium tuberculosis


Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Cytochrome P450 130 Chains: A, B
Molecule details ›
Chains: A, B
Length: 414 amino acids
Theoretical weight: 45.84 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P9WPN5 (Residues: 1-405; Coverage: 100%)
Gene names: MTCY50.26, Rv1256c, cyp130
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P3221
Unit cell:
a: 130.676Å b: 130.676Å c: 229.357Å
α: 90° β: 90° γ: 120°
R R work R free
0.2 0.2 0.234
Expression system: Escherichia coli BL21(DE3)