2uuy

X-ray diffraction
1.15Å resolution

Structure of a tick tryptase inhibitor in complex with bovine trypsin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cationic trypsin Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.32 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00760 (Residues: 24-246; Coverage: 97%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Tryptase inhibitor Chain: B
Molecule details ›
Chain: B
Length: 52 amino acids
Theoretical weight: 5.79 KDa
Source organism: Rhipicephalus appendiculatus
UniProt:
  • Canonical: Q1EG59 (Residues: 45-95; Coverage: 53%)
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 46.949Å b: 67.69Å c: 69.068Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.132 0.13 0.163