› 2uus

X-ray diffraction
2.2Å resolution

Crystal structure of the rat FGF1-sucrose octasulfate (SOS) complex.

Released:
DOI: 10.2210/pdb2uus/pdb
PDB entry 2uus coloured by chain, front view.
PDB entry 2uus coloured by chain, side view.
PDB entry 2uus coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Dimerization effect of sucrose octasulfate on rat FGF1.
Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M
Acta Crystallogr Sect F Struct Biol Cryst Commun 64 448-52 (2008)
PMID: 18540049

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158226 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Fibroblast growth factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 132 amino acids
Theoretical weight: 14.97 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P61149 (Residues: 22-153; Coverage: 85%)
Gene names: Fgf-1, Fgf1, Fgfa
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

Carbohydrate polymer : NEW Components: GU4, YYJ
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21
Unit cell:
a: 36.883Å b: 52.778Å c: 73.127Å
α: 90° β: 97.43° γ: 90°
R-values:
R R work R free
0.21 0.206 0.277
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Sucrose octasulfate selectively accelerates thrombin inactivation by heparin cofactor II.
Sarilla et al. (2010)
2 more

2 mentions without citation

Interaction of thrombin with sucrose octasulfate.
Desai et al. (2011)
1 more