› 2rrm

Solution NMR

Interplay between phosphatidyl-inositol-phosphates and claudins upon binding to the 1st PDZ domain of zonula occludens 1

Released:
DOI: 10.2210/pdb2rrm/pdb
PDB 2rrm coloured by chain and viewed from the front.
PDB 2rrm coloured by chain and viewed from the side.
PDB 2rrm coloured by chain and viewed from the top.
Source organism: Mus musculus
Primary publication:
1H, 13C, and 15N resonance assignment of the first PDZ domain of mouse ZO-1.
Umetsu Y, Goda N, Taniguchi R, Satomura K, Ikegami T, Furuse M, Hiroaki H
Biomol NMR Assign 5 207-10 (2011)
PMID: 21431884

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tight junction protein ZO-1 Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 10.82 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P39447 (Residues: 18-110; Coverage: 5%)
Gene names: Tjp1, Zo1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Chemical shifts: BMR11424  
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Discovery of Cryoprotective Activity in Human Genome-Derived Intrinsically Disordered Proteins.
Matsuo et al. (2018)
2 more

3 mentions without citation

Accidental interaction between PDZ domains and diclofenac revealed by NMR-assisted virtual screening.
Tenno et al. (2013)
2 more